The purpose of this study is to conduct an initial investigation into whether an alternative method of using 3D imaging might offer accurate diagnostic performance at a reduced patient radiation exposure in comparison to conventional 2D screening and diagnostic mammography and conventional 2D + 3D imaging methods.

Inclusion Criteria:

• Subject is female of any race and ethnicity
• Subject is at least 40 years old
• The screening and diagnostic mammograms were performed at the recruiting institution on a Hologic Selenia System
• Subject is categorized as BI-RADS 0 because if mass, density, or calcifications detected on the basis of screening or diagnostic mammography
• Subject will undergo study imaging within 30 days of standard of care imaging

Exclusion Criteria:

• Patients who are pregnant or think they may be pregnant
• Patients who are breast feeding
• Subjects unable or unwilling to undergo informed consent
• Subjects with breast implants