Post-operative Crohn's Endoscopic Recurrence Study

Post-Operative Crohn's Disease Endoscopic Recurrence "POCER" Study: Endoscopic Guided Therapeutic Intervention & Determination of Cause

This randomised, controlled study aims to evaluate the impact of endoscopic assessment, and adjustment of therapy, after surgery in patients with Crohn's disease. The primary endpoint is the severity of endoscopic recurrence. In addition, tissue will be collected for microbiological and immunological analysis.

Inclusion Criteria:

• clinical diagnosis of Crohn's and proven history of disease
• patient undergone surgical resection with creation of a primary anastomosis

Exclusion Criteria:

• endoscopically inaccessible anastomosis by standard colonoscopy
• presence of an end stoma
• pregnancy
• suspected perforation of the gastrointestinal tract
• presence of certain unsuitable comorbidities