Individual Differences in Diabetes Risk: Role of Slow WaveSleep

Ancillary Studies to Major Ongoing NIDDK Clinical Research Studies

This study will examine the relationship between the amount of slow wave sleep (deep sleep) and the ability of the body to bring the blood sugar level to a normal range after receiving glucose.

Inclusion Criteria:

• healthy volunteers age 18-20 with a BMI < 27kg/m2 in women and < 28 kg/m2 in men with normal findings on clinical examination, routine laboratory tests and EKG
• only subjects who have regular life styles (no shift work, no travel across time zone during the previous 4 weeks)
• habitual bedtimes between 7.0-8.5 hours/night
• do not take medications will be recruited

Exclusion Criteria:

• women taking hormonal contraceptive therapy and pregnant women will be excluded
• individuals with a history of psychiatric, endocrine, cardiac or sleep disorders will be excluded
• other exclusion criteria will be: tobacco use, habitual alcohol use of more than 1 drink per day, excessive caffeine intake of more than 300 mg per day