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Patients with stage-I multiple myeloma are treated with a vaccine made from their own immune cells (dendritic cells) and their own myeloma protein. Vaccinations are given on 5 occasions every 4 weeks. The aim is to induce an immune reaction against the malignant myeloma cells in order to slow down or cure the disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| s.c. vaccination | Experimental | vaccine given subcutaneously |
|
| i.v. vaccination | Experimental | vaccines are given intravenously |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| autologous idiotype-protein pulsed dendritic cells | Biological | Vaccination with autologous idiotype-protein pulsed dendritic cells on 5 occasions every 4 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Specific T-cell proliferation/cytokine secretion |
| Measure | Description | Time Frame |
|---|---|---|
| number of T cells | pre and post vaccination | |
| monoclonal protein | pre and post vaccination | |
| plasmacells in bone marrow |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Susanne Gretzinger, MD | University Hospital Dresden | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Dresden | Dresden | 01307 | Germany |
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| ID | Term |
|---|---|
| D009101 | Multiple Myeloma |
| D010954 | Plasmacytoma |
| ID | Term |
|---|---|
| D054219 | Neoplasms, Plasma Cell |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D020141 | Hemostatic Disorders |
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| pre and post vaccination |
| vital signs | pre and post vaccination |
| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010265 | Paraproteinemias |
| D001796 | Blood Protein Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006474 | Hemorrhagic Disorders |
| D008232 | Lymphoproliferative Disorders |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |