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| Name | Class |
|---|---|
| University of Ljubljana School of Medicine, Slovenia | OTHER |
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With the use of molecular methods new viruses have been detected in respiratory and gastrointestinal tracts of both patients and asymptomatic subjects in recent years. The clinical importance of these viruses has not been adequately studied.
The aim of this study is to use molecular methods to detect viruses in upper respiratory tract and gastrointestinal tract of children with acute bronchiolitis, acute gastroenteritis and febrile convulsions and to try to correlate the severity of clinical picture with the amount of viruses present in clinical samples. The investigators will also try to detect the increase in specific antibodies in paired sera.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute bronchiolitis | Patients with acute bronchiolitis - the presence of nasal discharge, cough, wheezing and/or crackles on lung auscultation. | ||
| Acute gastroenteritis | Patients with 3 or more loose or liquid stools in 24 hours prior to entering the study. | ||
| Febrile convulsion | Patients with a cerebral paroxysm accompanied by fever without signs of central nervous system infection. | ||
| Control group | Patients referred to pediatric surgery for elective surgical procedure - judged to be free of clinical signs and symptoms of infection. |
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| Measure | Description | Time Frame |
|---|---|---|
| To describe the clinical picture of a viral respiratory and/or gastrointestinal infection associated with a specific viral pathogen | In a 14-day period |
| Measure | Description | Time Frame |
|---|---|---|
| To correlate the severity of clinical picture with the quantity of virus in clinical samples | In a 14-day period |
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Inclusion Criteria:
presence of
Exclusion Criteria:
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Children under 6 years of age admitted to Department of Infectious Diseases, University Medical Centre Ljubljana with a diagnosis of acute bronchiolitis, acute gastroenteritis or febrile convulsion.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marko Pokorn, MD, MSc | Contact | +38641712241 | marko.pokorn@mf.uni-lj.si | |
| Tatjana Mrvič, MD, MSc | Contact | +38615222110 | tatjana.mrvic@guest.arnes.si |
| Name | Affiliation | Role |
|---|---|---|
| Marko Pokorn, MD, MSc | Department of Infectious Diseases, University Medical Centre Ljubljana | Principal Investigator |
| Franc Strle, MD, PhD | Department of Infectious Diseases, University Medical Centre Ljubljana |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Infectious Diseases, University Medical Centre Ljubljana | Recruiting | Ljubljana | 1000 | Slovenia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41392358 | Derived | Jevsnik Virant M, Petrovec M, Strle F, Mrvic T, Pokorn M, Grosek S, Ursic T. Influenza C Virus in Children With Acute Bronchiolitis and Febrile Seizures. Pediatr Infect Dis J. 2026 May 1;45(5):432-436. doi: 10.1097/INF.0000000000005089. Epub 2025 Dec 15. | |
| 27698149 | Derived | Pokorn M, Jevsnik M, Petrovec M, Steyer A, Mrvic T, Grosek S, Lusa L, Strle F. Respiratory and Enteric Virus Detection in Children. J Child Neurol. 2017 Jan;32(1):84-93. doi: 10.1177/0883073816670820. Epub 2016 Oct 3. |
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| ID | Term |
|---|---|
| D001988 | Bronchiolitis |
| D005759 | Gastroenteritis |
| D003294 | Seizures, Febrile |
| ID | Term |
|---|---|
| D001991 | Bronchitis |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D001982 | Bronchial Diseases |
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Whole blood, stool and nasopharyngeal swab samples.
| Miroslav Petrovec, MD, PhD | Institute of Microbiology and Immunology | Principal Investigator |
| Department of Pediatric Surgery, University Medical Centre Ljubljana | Recruiting | Ljubljana | 1000 | Slovenia |
|
| Institute of Microbiology and Immunology | Not yet recruiting | Ljubljana | 1000 | Slovenia |
|
| 27171141 | Derived | Jevsnik M, Steyer A, Pokorn M, Mrvic T, Grosek S, Strle F, Lusa L, Petrovec M. The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study. PLoS One. 2016 May 12;11(5):e0155555. doi: 10.1371/journal.pone.0155555. eCollection 2016. |
| 23379823 | Derived | Jevsnik M, Steyer A, Zrim T, Pokorn M, Mrvic T, Grosek S, Strle F, Lusa L, Petrovec M. Detection of human coronaviruses in simultaneously collected stool samples and nasopharyngeal swabs from hospitalized children with acute gastroenteritis. Virol J. 2013 Feb 5;10:46. doi: 10.1186/1743-422X-10-46. |
| D012140 |
| Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D012640 | Seizures |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |