Sentinel Node and Endometrial Cancer

Validation of the Sentinel Node in Endometrial Cancer

The purpose of this study is to investigate the relevance of sentinel node in endometrial cancer. Sentinel node is thought to reflect the status of lymph node. Only 10 to 20% of women with endometrial cancer exhibit lymph node metastasis hence systematic lymphadenectomy is questionable. In breast cancer, melanoma and vulvar cancer, sentinel node has emerged as an alternative to complete lymphadenectomy.

To investigate the relevance of sentinel node in endometrial cancer. Sentinel node is though to reflect the status of lymph node. Only 10 to 20% of women with endometrial cancer exhibit lymph node metastasis hence systematic lymphadenectomy is questionable. In breast cancer, melanoma and vulvar cancer, sentinel node has emerged as an alternative to complete lymphadenectomy. The objective of our trial is to validate the concept of sentinel node in endometrial cancer.

Inclusion Criteria:

• patient over 18 years old with a surgery planned for endometrial cancer
• endometrial cancer proved by biopsy
• early stage of endometrial cancer (FIGO stage 1-2)
• without contraindication to surgery
• inform consent signed
• affiliated to general health system

Exclusion Criteria:

• endometrial cancer FIGO stages 3-4
• previous history of surgery modifying lymphatic drainage (conization myomectomy)
• pregnant women or breast feeding