A Midazolam Drug Interaction Study With PF-04171327

A Phase 1, Open Label, Multiple Dose Study Of The Effect Of PF-04171327 On Midazolam Pharmacokinetics In Healthy Volunteers

The purpose of this study is to investigate the effects of multiple doses of PF-04171327 on the blood levels (pharmacokinetics) of midazolam

Inclusion Criteria:

• Healthy males and/or females (non-childbearing potential) volunteers.
• Cortisol level within normal reference range of the laboratory.

Exclusion Criteria:

• History of intolerance or significant adverse effect with glucocorticoid (steroid) therapy.
• History or current positive results for HIV, Hepatitis B or C or active TB or currently undergoing treatment for TB.
• Known history of hypersensitivity, allergy severe drug reaction or unable to tolerate midazolam or other benzodiazepines.