Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation

The purpose of this study is to determine whether inhalation with aerosolized amphoterin B 10mg/d is more effective than aerosolized amphoterin B 2mg/d to reduce the incidence of invasive pulmonary aspergillosis.

Inclusion Criteria:

• 65ys≥age≥18ys
• renal transplant recipients

Exclusion Criteria:

• subjects with hypersensitivity to amphotericin B
• receipt of inhalational or intravenous amphotericin B within last 30 days
• subjects with known invasive fungal infection before renal transplant
• subjects with pneumonia