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| ID | Type | Description | Link |
|---|---|---|---|
| SCCC-05509 | |||
| 072009-061 |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
PURPOSE: This phase I trial is studying the side effects and best dose of specialized radiation therapy in treating patients with stage II, stage III, stage IV, or recurrent non-small cell lung cancer and poor performance status.
OBJECTIVES:
Primary
Secondary
OUTLINE: Patients undergo accelerated hypofractionated image-guided conformal radiotherapy once daily, 5 days a week, for 3 weeks (15 fractions). Treatment continues in the absence of disease progression or unacceptable toxicity.
After completion of study therapy, patients are followed up periodically for up to 5 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| arm one | Other | IGRT |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hypofractionated radiation therapy | Radiation | hypofractionated radiation therapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dose-limiting toxicity | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Local regional tumor control | 6 month | |
| Overall survival | 2 year |
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DISEASE CHARACTERISTICS:
Histologically or cytologically confirmed non-small cell lung cancer
Measurable or evaluable disease
No prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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| Name | Affiliation | Role |
|---|---|---|
| Robert D. Timmerman, MD | Simmons Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | 94305 | United States | ||
| University of Texas Southwestern Medical Center |
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| Dallas |
| Texas |
| 75390 |
| United States |
| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D002289 | Carcinoma, Non-Small-Cell Lung |
| D000077192 | Adenocarcinoma of Lung |
| D002282 | Adenocarcinoma, Bronchiolo-Alveolar |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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