The Effects AZD8529 on Ketamine-induced Impairment of Working Memory in Healthy Volunteers

A Single Center, Double-Blind, Randomized, Double Dummy, Placebo-Controlled, Three-Period Crossover Study to Assess the Effects of a mGluR2/3 Positive Allosteric Modulator [AZD8529] Upon Ketamine-Induced Cortical Stimulation and Impairment of Working-Memory Related Activation of the Prefrontal Cortex

The purpose of this study is to assess if ketamine will induce, in healthy volunteers, impairment of working memory and if the drug AZD8529 will block the effects of ketamine on working memory as assessed by functional magnetic resonance imaging (fMRI).

Inclusion Criteria:

• Right handed
• 12th grade education or equivalent
• Able to read and write English as primary language

Exclusion Criteria:

• History of head injury
• Substance abuse or dependence
• History of claustrophobia