A Study of ProQuad in Healthy 4 to 6 Year Old Children (V221-014)

Administration of Frozen Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine to Healthy Children at 4 to 6 Years of Age

The study was conducted to determine if ProQuad may be used in place of the second dose of M-M-R II routinely given to children 4 to 6 years old who were previously immunized with M-M-R II and Varivax.

Inclusion Criteria:

• In good health
• Received primary dose of M-M-R II at less than or equal to 12 months of age
• Received primary dose of Varivax at less than or equal to 12 months of age
• Negative history of varicella, zoster, measles, mumps, and rubella

Exclusion Criteria:

• history of receiving more than once dose of M-M-R II or Varivax
• Any immune impairment or deficiency
• Exposure to measles, mumps, rubella, varicella, or zoster in the 4 weeks prior to vaccination
• Vaccination with an inactive vaccine with in the past 14 days
• Vaccination with a live vaccine within the past 30 days
• Receipt of immune globulin, or blood product in the past 5 months