Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The authors finished their jobs in the hospitals where the study was begun.
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Hospital General "Dr. Darío Fernández Fierro" | UNKNOWN |
| National Institute of Neurology and Neurosurgery | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Objective:
Report manganese serum levels and mortality in encephalopathic patients.
Patients and participants:
Consecutive patients aged > 18 years, with hepatic encephalopathy and informed consent signed by their families.
Interventions:
Patients' clinical characteristics as well as biochemical tests of renal function, hemoglobin, glucose and albumin levels were obtained as well as a blood sample to analyze manganese levels with a graphite furnace atomic absorption spectrometer.
Hypothesis:
There is a difference in the manganese levels between male and female patients.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Evolution | Number of participants who died versus those who remained alive after 6 months of follow up since the first entrance at the Emergency Room | six months |
| Measure | Description | Time Frame |
|---|---|---|
| Manganese Levels | From encephalopathic patients, we took individual blood samples, analyzed in the biochemistry laboratory at the National Institute of Neurology and Neurosurgery, Mexico, City, with a graphite furnace atomic absorption spectrometer, according to the technique reported by Pleban. | Up to six months we followed the recruited patients to determine who were still alive |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Consecutive patients aged > 18 years, with hepatic encephalopathy and informed consent signed by their families.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Hugo Mendieta Zerón, PhD | Materno-Perinatal Hospital of the State of Mexico | Principal Investigator |
| Camilo Rios Castañeda, PhD | National Institute of Neurology and Neurosurgery | Study Director |
| Mónica Rodríguez Rodríguez, MD | General Hospital "Dr. Darío Fernández Fierro" | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| General Hospital "Dr. Darío Fernández Fierro" | México | D.f. | 03900 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21975221 | Derived | Zeron HM, Rodriguez MR, Montes S, Castaneda CR. Blood manganese levels in patients with hepatic encephalopathy. J Trace Elem Med Biol. 2011 Dec;25(4):225-9. doi: 10.1016/j.jtemb.2011.07.003. Epub 2011 Oct 4. |
Not provided
Not provided
They were consecutive patients males or females aged > 18 years, with hepatic encephalopathy.
Encephalopathic patients admitted at the Department of Internal Medicine of the General Hospital "Dr. Darío Fernández Fierro" after being stabilized at the Emergency Room
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | Females | Brain death |
| FG001 | Males | Brain death |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Females | Brain death |
| BG001 | Males | Brain death |
| BG002 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Clinical Evolution | Number of participants who died versus those who remained alive after 6 months of follow up since the first entrance at the Emergency Room | We made a clinical follow up from nine encephalopathic patients. After six months we studied the differences in Mn, hemoglobin, etc., between those patients still alive and those who died. | Posted | Number | participants | six months |
|
Not provided
Not provided
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Females | Brain death |
Not provided
Not provided
Small numbers of subjects analyzed
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Hugo Mendieta Zerón | Materno-Perinatal Hospital of the State of Mexico | +52-722-2176605 | mezh_74@yahoo.com |
Not provided
| ID | Term |
|---|---|
| D006501 | Hepatic Encephalopathy |
| D006526 | Hepatitis C |
| ID | Term |
|---|---|
| D017093 | Liver Failure |
| D048550 | Hepatic Insufficiency |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| Total |
Total of all reporting groups |
| years |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex/Gender, Customized | Number | participants |
|
| Region of Enrollment | Number | participants |
|
| Baseline blood hemoglobin | Blood samples when arriving at the Emergency Room were used to measure hemoglobin | Mean | Standard Deviation | mg/dL |
|
| Blood levels of manganese | Blood levels of manganese in patients with encephalopathy when arriving at the Emergency Room | Mean | Standard Deviation | µg/L |
|
| Units | Counts |
|---|
| Participants |
|
|
|
| Secondary | Manganese Levels | From encephalopathic patients, we took individual blood samples, analyzed in the biochemistry laboratory at the National Institute of Neurology and Neurosurgery, Mexico, City, with a graphite furnace atomic absorption spectrometer, according to the technique reported by Pleban. | All patients attended at the Internal Medicine Service with Hepatic Encephalopathy were included. The analysis was per protocol. | Posted | Mean | Standard Deviation | μg/L | Up to six months we followed the recruited patients to determine who were still alive |
|
|
|
|
| 0 |
| 4 |
| 0 |
| 4 |
| EG001 | Males | Brain death | 0 | 5 | 0 | 5 |
Not provided
Not provided
| D001928 |
| Brain Diseases, Metabolic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D006525 | Hepatitis, Viral, Human |
| D014777 | Virus Diseases |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006505 | Hepatitis |