Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery

Impact of a Biological Glue (Evicel®) on the Peri Operative Bleeding in Total Knee Prothesis Surgery

Knee prothesis surgery is responsible of a risk of thrombosis and hemorrhage. To prevent thrombosis, patients have systematic anticoagulation after surgery which are responsible of hemorrhage. A local glue which improve local coagulation and have no impact of thrombosis can be a solution to limit hemorrhage. The purpose of this trial is to study the impact of a biological glue administration on the bleeding loss at five days after a total knee prosthesis surgery operation.

The orthopaedic surgeon administers a local pulverisation of the biological glue during the surgery.

Inclusion Criteria:

• Patient affiliated with or a beneficiary of a social security category:

  • having more than 18 years old
  • having signed the informed consent form
  • having undergone a total knee prosthesis surgery operation

Exclusion Criteria:

• incapacity to understand the protocol
• patient having taken anti-coagulants or clopidogrel 10 days before excepted aspirin to a dose equal or less than 160 mg/day
• women having period so generally women having less than 50 years old
• PT less than 60% and ACT taller than 10 sec
• contra-indications to the drug
• Erytropoietine treatment required before surgery