Pilot Assessment of Lopinavir/Ritonavir and Maraviroc

Pilot Assessment of Lopinavir/Ritonavir and Maraviroc in Experienced Patients

This is a study to assess the response of lopinavir/ritonavir plus maraviroc (with no nucleoside medications) in HIV patients failing their initial antiviral therapy.

As long-term toxicity to many of the nucleoside medications have become known, interest has increased in treatment regimens that do not use these medications. This study is to assess the response of one such "nucleoside-sparing" therapy in patients who are showing failure to their initial nucleoside-containing treatment regimen.

Inclusion Criteria:

• HIV viral load > 1,000 on current antiviral medications
• No resistance to study medications
• Over 18 years of age

Exclusion Criteria:

• Hepatitis B co-infection
• Pregnancy
• Previous therapy with either of the study medications
• Ongoing substance abuse
• Significant history of other physical disease