Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The hippocampus is particularly laden with n-methyl-d-aspartate (NMDA) receptors, and is at the same time one of the most important sites in declarative memory. The rationale of this study is that the NMDA partial agonist D-Cycloserine will promote learning compared to a placebo. On the other hand, the NMDA receptor antagonist Memantine might lead to reduced memory. We believe that the influence of NMDA receptors on memory can be determined via acute co-activation of the NMDA receptors with Cycloserine® (King Pharmaceuticals Ltd, active ingredient: DCycloserin, dose: 250 mg) and Memantine (Axura®, Merz, active ingredient: Memantine, dose: 20 mg)on both a behavioral and functional (fMRI) level.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sugar pill, behavioral glutamic acid | Placebo Comparator | Placebo condition for D-Cycloserine |
|
| Sugar pill, fMRI, glutamic acid | Placebo Comparator | Placebo condition for D-Cycloserine, fMRI |
|
| Sugar pill, memantine, behavioral | Placebo Comparator | Placebo condition Memantine, behavioral |
|
| Sugar pill, memantine, fMRI | Placebo Comparator | Placebo condition Memantine, fMRI |
|
| D-Cycloserine behavioral | Active Comparator |
| |
| D-Cycloserine, fMRI | Active Comparator |
| |
| Memantine, behavioral |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sugar pill | Drug | 250 mg, one dose, 60 min prior |
|
| Measure | Description | Time Frame |
|---|---|---|
| fMRI during learning task | once at drug administration |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Forschungszentrum Juelich GmbH | Jülich | North Rhine-Westphalia | 52428 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20303474 | Derived | Onur OA, Schlaepfer TE, Kukolja J, Bauer A, Jeung H, Patin A, Otte DM, Shah NJ, Maier W, Kendrick KM, Fink GR, Hurlemann R. The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans. Biol Psychiatry. 2010 Jun 15;67(12):1205-11. doi: 10.1016/j.biopsych.2010.01.022. Epub 2010 Mar 20. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000073893 | Sugars |
| D003523 | Cycloserine |
| D018698 | Glutamic Acid |
| D008559 | Memantine |
| ID | Term |
|---|---|
| D002241 | Carbohydrates |
| D007555 | Isoxazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Active Comparator |
|
| Memantine, fMRI | Active Comparator |
|
| Sugar pill | Drug | 250 mg, one dose, 60 min prior |
|
|
| Sugar pill | Drug | 20 mg, one dose, 8 hours prior |
|
|
| Sugar pill | Drug | 20 mg, one dose, 8 hours prior |
|
|
| Glutamic Acid | Drug | 250 mg, one dose, 60 minutes prior |
|
|
| Glutamic Acid | Drug | 250 mg, one dose, 60 minutes prior |
|
|
| Memantine | Drug | 20 mg, one dose, 8 hours prior |
|
|
| Memantine | Drug | 20 mg, one dose, 8 hours prior |
|
|
| D006571 |
| Heterocyclic Compounds |
| D023303 | Oxazolidinones |
| D010080 | Oxazoles |
| D012694 | Serine |
| D021542 | Amino Acids, Neutral |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D005971 | Glutamates |
| D024342 | Amino Acids, Acidic |
| D000600 | Amino Acids, Dicarboxylic |
| D018846 | Excitatory Amino Acids |
| D000547 | Amantadine |
| D000218 | Adamantane |
| D001952 | Bridged-Ring Compounds |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |