The Arthritis, Diet, and Activity Promotion Trial

The Arthritis, Diet, and Activity Promotion Trial

The primary purpose of this study was to determine the effect of dietary weight-loss, exercise training, or a combination of both on physical function in overweight and obese adults with knee osteoarthritis (OA). In secondary analyses, the effect of weight-loss and/or exercise on OA progression, self-reported pain and inflammation were examined. In post-trial analyses, the effect of dietary weight-loss on total mortality was determined.

Inclusion Criteria:

• Age ≥ 60 years.
• BMI ≥ 28 kg/m2.
• Knee pain on most days of the month.
• Sedentary lifestyle pattern (<20 min exercise per week for last 6 months)
• Self-reported difficulty with at least one of the following: walking 1/4 mile, climbing stairs, kneeling, bending, stooping, shopping, lifting, self-care.
• Radiographic evidence of grade 1-3 knee osteoarthritis.

Exclusion Criteria:

• Serious medical condition that precludes safe participation in exercise such as heart disease (angina, congestive heart failure), severe hypertension, COPD, renal or liver disease, insulin-dependent diabetes.
• Mini-mental state exam score <24.
• Inability to walks without a cane.
• Reported alcohol consumption >14 drinks/week.
• Inability to complete protocol.
• ST segment depression.
• Participation in another research study.