Microenvironment of Adipose Tissue in Endocannabinoid System

Microenvironment of Adipose Tissue in Endocannabinoid System Before and After Roux-en-y Gastric Bypass Surgery

The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.

Inclusion Criteria:

• BMI>35 kg/m2
• Age 20-60 yrs
• Approved and scheduled for gastric bypass surgery
• Stable body weight for past 3 months

Exclusion Criteria:

• Positive pregnancy test
• Previous gastric surgeries
• Intercurrent infections
• History of ketoacidosis or current metabolic acidosis
• Serum creatinine or liver function tests > 2 times upper limits of normal
• Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.