Platelet Hyperreactivity Project

Platelet Hyperreactivity Project: A System Biology Approach of High On-treatment Platelet Reactivity in Aspirin-treated Cardiovascular Patients

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients.

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients using a system biology approach that include proteomics analysis of selected platelet sub-fractions in patients displaying extreme phenotype.

Main objective:

• to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients

Secondary objectives:

• to characterize the platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin
• to determine genetic polymorphisms associated with platelet hyperreactivity

Inclusion Criteria:

• Documented symptomatic ischemic atherothrombotic disease treated by aspirin.

Exclusion Criteria:

• Known platelet disorder
• Chronic treatment by antiplatelet drugs other than aspirin
• Chronic anticoagulant treatment
• Chronic non steroidal anti-inflammatory drug treatment
• Active cancer
• Treatment with serotonin reuptake inhibitors