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| Name | Class |
|---|---|
| Blue Cross Blue Shield | OTHER |
| Cardiovascular Imaging Technologies | INDUSTRY |
| Saint Luke's Cardiovascular Consultants | OTHER |
| Mid America Heart Institute |
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The purpose of this study is to compare pharmacologic stress myocardial perfusion PET with pharmacologic stress myocardial perfusion SPECT in a near-simultaneous, head-to-head comparison in the same patient. The investigators hypothesize that pharmacologic stress myocardial perfusion PET will prove superior to pharmacologic stress myocardial perfusion SPECT as a first-line diagnostic test for higher-risk patients with known coronary artery disease (CAD) who present with symptoms consistent with possible worsening of their CAD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SPECT myocardial perfusion imaging | Active Comparator |
| |
| PET myocardial perfusion imaging | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Myocardial perfusion imaging | Procedure | Randomization assignment to one of SPECT or PET myocardial perfusion imaging |
|
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic failure of SPECT vs PET | 60 days |
| Measure | Description | Time Frame |
|---|---|---|
| Composite of diagnostic or clinical failure | 12 months | |
| Each of individual components of clinical failure | 12 months | |
| Relative effect on quality of life |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Timothy M Bateman, M.D. | Aspire Foundation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint Luke's Cardiovascular Consultants | Kansas City | Missouri | 64111 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31326480 | Derived | Patel KK, Al Badarin F, Chan PS, Spertus JA, Courter S, Kennedy KF, Case JA, McGhie AI, Heller GV, Bateman TM. Randomized Comparison of Clinical Effectiveness of Pharmacologic SPECT and PET MPI in Symptomatic CAD Patients. JACC Cardiovasc Imaging. 2019 Sep;12(9):1821-1831. doi: 10.1016/j.jcmg.2019.04.020. Epub 2019 Jul 17. |
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| OTHER |
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| 3 months, 6 months |
| Relative direct and downstream costs | 3 months, 6 months, 12 months |
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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