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| Name | Class |
|---|---|
| State University of New York - Downstate Medical Center | OTHER |
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The purpose of this study is to investigate the effect of lidocaine in antiarrhythmic dosage on postoperative cognitive dysfunction in supratentorial craniotomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Saline | Placebo Comparator |
| |
| Lidocaine | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lidocaine | Drug | Lidocaine arm: lidocaine (2%) as an intravenous bolus (1.5 mg/kg) during induction followed by an intravenous infusion (2 mg. kg(-1).h(-1)) after induction until at the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Mini-Mental State Examination (MMSE) | Preoperatively, 3 days and 3 months postoperatively | |
| Montreal Cognitive Assessment (MoCA) | Preoperatively, 3 days and 3 months postoperatively | |
| Hamilton Depression Scale (HAMD) | Preoperatively, 3 days and 3 months postoperatively | |
| Clinical Dementia Rating (CDR) | Preoperatively, 3 days and 3 months postoperatively | |
| Confusion Assessment Method for the Diagnosis of Delirium in the Intensive Care unit (ICU) (CAM-ICU) | 1 day and 3 days postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| AjDO2 (Arterial Jugular Difference) | Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery | |
| AjDGlc | Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology,Beijing Tiantan Hospital, Capital Medical University | Beijing | Beijing Municipality | 100050 | China |
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| saline | Drug | Saline arm: infused at the same rate as lidocaine |
|
| AjDGlutamate | Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery |
| AjDLct | Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery |
| S100 | Injection of test dosage, end of surgery, 24 hours after operation |
| Amyloid-β protein(Aβ) | Injection of test dosage, end of surgery, 24 hours after operation |
| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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