CompletedInterventionalNot ApplicableUpdated Feb 16, 2024
Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial... | NCT00975910 | Trialant
CompletedInterventionalPhase 2Updated May 22, 2013
Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial Craniotomy
ClinicalTrials.gov ID
NCT00975910
Lead Sponsor
Capital Medical UniversityOTHER
Overall Status
Completed
Study Type
Interventional
Phase
Phase 2
Enrollment
100Actual
Last Update Posted
May 22, 2013Estimated
Start Date
Sep 2009
Primary Completion Date
May 2012Actual
Completion Date
Dec 2012Actual
Brief Summary
The purpose of this study is to investigate the effect of lidocaine in antiarrhythmic dosage on postoperative cognitive dysfunction in supratentorial craniotomy.
Supratentorial Craniotomy Dysfunction
lidocaine
saline
Ages Eligible for Study
Adult (18-64)
Sexes Eligible for Study
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
18-60 years old, ASA physical status I or II, BMI<30
Scheduled for elective supratentorial craniotomy
MMSE<24 before operation
Cooperative and given informed consent in person
Exclusion Criteria:
History of mental or psychiatric disorders
Contraindicated to internal jugular venous catheterization
Pregnant or lactating female
History of systemic malignant tumor or diabetes
Previously treated with this protocol or participated in another study within previous 30 days
Suspected history of allergic reaction or intolerance to amides or other anesthetic agents in this study
History of alcohol abuse and/or drug abuse within previous one year
History or a family history of malignant hyperthermia
Primary Purpose
Supportive Care
Allocation
Randomized
Interventional Model
Parallel Assignment
Masking
Double
No central contacts
There are no central contacts for this study.
Department of Anesthesiology,Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality 100050, China
Lead Sponsor
Capital Medical UniversityOTHER
Collaborators
State University of New York - Downstate Medical CenterOTHER