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| Name | Class |
|---|---|
| Nanjing Maternity and Child Health Care Hospital | OTHER |
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Fluid management plays an essential role in cesarean section. In previous study (NCT00488111) the investigators found that prior-epidural anesthesia fluid management produced a more significant role in stabilizing the blood pressure and better prognosis after cesarean delivery than that of the posterior-anesthesia ones. Given epidural anesthesia has a time interval before reaching the best state of anesthesia, so the fluid management also has a relatively adequate time to resuscitation. In reality, spinal anesthesia is used popularly except for the epidural anesthesia, whereas spinal anesthesia would produce more significant fluctuation of the hemodynamics compared with the latter. Herein the investigators proposed whether the prior-spinal anesthesia fluid management also produced similar effect on hemodynamic characteristics to the epidural anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prior crystalloid | Active Comparator | Crystalloid (Ringer's Lactate) was given before spinal anesthesia |
|
| Posterior crystalloid | Active Comparator | Crystalloid (Ringer's Lactate) was given after spinal anesthesia |
|
| Prior colloid | Active Comparator | Colloid (6% hydroxyethyl starch) was given before spinal anesthesia |
|
| Posterior colloid | Active Comparator | Colloid (6% hydroxyethyl starch) was given after spinal anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ringer's Lactate | Drug | Ringer's Lactate 8 ml/kg was given intravenously before or after spinal anesthesia in cesarean section |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of hypotension | Anesthesia begin (0 min) to 120 min after anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence of hypotension after ephedrine or phenylephrine | Anesthesia begin (0 min) to 120 min after anesthesia | |
| Consumption of ephedrine and phenylephrine | Anesthesia begin (0 min) to 120 min after anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| XiaoFeng Shen, MD | Nanjing Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Affiliated Nanjing Maternity and Child Health Care Hospital | Nanjing | Jiangsu | 210004 | China |
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| ID | Term |
|---|---|
| D000077325 | Ringer's Lactate |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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|
| Six percent hydroxyethyl starch | Drug | Hydroxyethyl starch (6%) was given before or after spinal anesthesia in cesarean section |
|
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| Total volume of colloid or crystalloid | Fifteen minutes before anesthesia to 120 min after anesthesia |
| One-min and 5-min Apgar scores | The first and fifth minute after cesarean successful delivery |
| Oxygen saturation during hypotension | Anesthesia begin (0 min) to 120 min after anesthesia |
| Duration of hypotension | Anesthesia begin (0 min) to 120 min after anesthesia |
| Low umbilical cord pH (artery < 7.20) | At the time of successful delivery (0 min) |