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| Name | Class |
|---|---|
| IWK Foundation | UNKNOWN |
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The purpose of this study is to assess whether smaller volumes of oral dexamethasone result in better tolerability, specifically less vomiting, in pediatric patients during an acute asthma exacerbation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10 mg/mL Unsweetened Formulation | Placebo Comparator | no prior vomiting |
|
| 1 mg/mL Ora Sweet Formulation | Experimental | no prior vomiting |
|
| 10 mg/mL Unsweetened with prior vomiting | Active Comparator | with prior vomiting |
|
| 1 mg/mL Ora Sweet with prior vomiting | Experimental | with prior vomiting |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ora Sweet | Drug | A pharmaceutical suspending vehicle and flavouring agent added to the dexamethasone. All arms received the same amount of dexamethasone based on the child's weight, only in different volumes. |
| Measure | Description | Time Frame |
|---|---|---|
| The primary objective of this study was to assess whether smaller volumes of oral dexamethasone resulted in better tolerability, specifically less vomiting, in pediatric patients with an acute exacerbation of asthma. | During Emergency Department visit |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate asthma symptom control post emergency room visit for acute asthma exacerbation. | 7-14 days following emergency dept visit |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lyn K Sonnenberg, MD | IWK Health Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IWK Health Centre | Halifax | Nova Scotia | B3K 6R8 | Canada |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Dexamethasone | Drug |
|
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |