Bioequivalence of Two Formulations of Ondansetron in Healthy Adults (0869-106)

An Open-Label, Randomized, Single-Dose, 2-Period Crossover Study to Determine the Bioequivalence of 2 Formulations of Ondansetron in Healthy Young Adult Male and Female Subjects

This study will assess the bioequivalence of a Merck clinical trial formulation of ondansetron compared to a non-U.S. marketed formulation of ondansetron.

Inclusion Criteria:

• If female, subject is not pregnant or breast-feeding
• Subject has been a nonsmoker for at least 6 months
• Subject is in good health

Exclusion Criteria:

• Subject has a history of high blood pressure, asthma, other pulmonary disease, Gastrointestinal (GI) abnormalities/peptic ulcers, or cardiovascular, liver, neurologic, or kidney disease
• Subject is a habitual and heavy consumer of caffeine