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Over the past few years it has become clear that our understanding of bladder physiology is inadequate to explain urge incontinence. This has forced us to re-evaluate what we know and do not know about bladder function and dysfunction. This has led to the identification and study of novel systems within the bladder that may contribute to abnormal sensations.
The investigators now suspect that the organic changes occurring in the bladder are not the whole story. For one group of patients with pathological urge there is growing evidence suggesting that there may be a strong psychological component. The idea now being put forward is that normal afferent peripheral information is perceived as abnormal and excessive, resulting in an increased desire to go to the bathroom: 'perceptual urge'. It is important to identify this group of patients since it will direct their treatment towards more cognitive approaches. Also, if such a psychological aetiology can be eliminated it would lead to a more focused and effective management of peripheral pathology with surgery or pharmacology.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OAB | Patients with overactive bladder syndrome |
| |
| Osteoporosis | Patients with osteoporosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Micturition diary | Other | On the micturition diary patients are asked to note every void and drink. With every void they are asked to estimate their bladder volume and grade their degree of desire to void. |
| Measure | Description | Time Frame |
|---|---|---|
| Defining differences in self-consciousness and HADS scores in patients with OAB | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Defining differences between self-consciousness and HADS scores between the two cohorts | 1 year | |
| Defining differences in quality of life between the two cohorts | 1 year |
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Inclusion Criteria (for patients with OAB):
Patients should have at least one episode of urge: sudden compelling desire to void which can not be postponed.
Inclusion Criteria (for patients with osteoporosis):
Exclusion Criteria (for patients with OAB):
Exclusion Criteria (for patients with osteoporosis):
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The study population consists of two groups: 1: patients with OAB; 2: patients with osteoporosis.
The patients with OAB will be reqruited from the outpatient clinic and website designed for patients with overactive bladder symptoms.
The patients with osteoporosis will be recruited from an electronic patient database.
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| Name | Affiliation | Role |
|---|---|---|
| Gommert van Koeveringe, MD, PhD, urologist | Maastricht University Medical Centre | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University Medical Centre | Maastricht | Limburg | 6202 AZ | Netherlands |
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| ID | Term |
|---|---|
| D053201 | Urinary Bladder, Overactive |
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001745 | Urinary Bladder Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| C018209 | 4-amino-4'-hydroxylaminodiphenylsulfone |
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| Hospital Anxiety and Depression scale | Other | This questionnaire is designed to screen for the presence of a mood disorder. |
|
| EuroQol-5D | Other | This questionnaire grades the health condition of the subject. |
|
| Self-consciousness questionnaire | Other | The questions tap cognitive, emotional, and physical appearance aspects of directing their attention to the self. |
|
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D059411 | Lower Urinary Tract Symptoms |
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |