Effects of Methylprednisolone After Total Hip Arthroplasty

Effects of Pre-operative Methylprednisolone (125mg iv) After Total Hip Arthroplasty: A Prospective, Randomized, Double-blind, Placebo-controlled Trail

The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after hip arthroplasty.

The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce time to fulfill discharge criteria.

In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total hip arthroplasty is still associated with postoperative pain and delayed rehabilitation. The investigators therefore decided to evaluate the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome in a well defined fast-track setup after hip arthroplasty.

Inclusion Criteria:

• Elective total hip arthroplasty
• Able to speak and understand danish
• Able to give informed consent

Exclusion Criteria:

• Alcohol or medical abuse
• Allergies to local anesthetics or methylprednisolone
• Age < 18 years
• Daily use of opioids or glucocorticoids
• Pregnancy or breastfeeding (fertile women)