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This study evaluates whether Mitomycin C is an effective alternative to septal splints in the treatment of nasal synechiae.
Nasal synechiae is an important cause for the failure of many a nasal surgery. Septal splints have been widely used for the treatment of nasal synechiae, but are associated significant morbidity until removal. To the best of our knowledge there are no studies in literature comparing Mitomycin C with septal splints as an atraumatic alternative in the treatment of nasal synechiae. This is a preliminary study taken up to evaluate the therapeutic efficacy of Mitomycin C in the treatment of nasal synechiae.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mitomycin C | Active Comparator | Cases recruited into this arm receive topical application of mitomycin c (1mg/ml)following surgical synechiolysis |
|
| Teflon septal splint | Active Comparator | Cases recruited into this arm receive insertion of teflon internal nasal septal splint following surgical synechiolysis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mitomycin C | Drug | Cotton wick soaked with 1mg/ml of mitomycin c placed for 2 minutes between the raw surfaces after synechiolysis with surgical blade no.15 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence or absence of synechiae | 1 week, 1 month, 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Symptoms and complications | 1 week, 1 month, 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| VIKRAM K BHAT, MS(ENT), DNB | Karnataka Institute of Medical Sciences | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karnataka Institute of Medical Sciences | Hubli | Karnataka | 580022 | India |
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| ID | Term |
|---|---|
| D000267 | Tissue Adhesions |
| ID | Term |
|---|---|
| D002921 | Cicatrix |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D016685 | Mitomycin |
| ID | Term |
|---|---|
| D008937 | Mitomycins |
| D045563 | Indolequinones |
| D011809 | Quinones |
| D009930 | Organic Chemicals |
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|
| Teflon nasal septal splint | Device | Teflon internal nasal septal splint placed between the raw surfaces and secured at the anterior end of septum with catgut 3-0 sutures, following synechiolysis with surgical blade no.15. Splint removed at the end of one week |
|
|
| D001389 |
| Azirines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |