Principal Investigator has left Sponsoring Instiution

This is a prospective study, that will follow participants over their course of treatment on Isotretinoin. All patients who are prescribed Isotretinoin for their acne treatment are registered in iPLEDGE. The iPLEDGE program involves a set of steps that the patient, physician and pharmacist must follow for the patient to take Isotretinoin. Patients will be asked if they are willing to participate in this research study to determine musculoskeletal changes in adolescents and young adults on systemic therapy using the highly sensitive magnetic resonance (MR) imaging modality. In addition to the MRI, participants will be asked if they are willing to give an extra sample of blood when their routine blood work is being done for iPLEDGE. This blood sample will be used to determine if there are any effects of isotretinoin on bone turnover markers.

Inclusion Criteria:

1. Registered in I-Pledge and has not started the Isotretinoin medication
2. Females and males ages 12-21 years old
3. Able to undergo 3 MRI scan

Exclusion Criteria:

1. Participants taking additional vitamin A, D or Calcium supplements
2. Previous musculoskeletal injuries (from incidental trauma, sports related injury or motorvehicle accidents, etc)
3. Clinical diagnosis of psoriasis, rheumatoid arthritis and/or Reiter's disease
4. relocation within the next 6 months
5. participation on a research study involving drug medication within the past 30 days

All subjects will be recruited from the UW-Madison, Department of Dermatology located at 1 South Park Street, Madison, Wisconsin. Study flyers and brochures will be posted in the waiting areas and clinic rooms at the UW Dermatology clinics. UW Dermatologist will identify patients that meet study criteria and ask if they are interested in research participation, then they will be referred to study personnel for more information.

Adolescents and young adults treated with systemic isotretinoin for recalcitrant inflammatory or nodular cystic acne.