Image-Guided Tumorboost of Bladder Cancer

Image-guided Tumorboost of Localized Unifocal Bladder Cancer: A Phase I/II Study

The purpose of the study is to increase the radiation dose (Boost) to the bladder tumor. The bladder cancer patients included in the study will undergo tumor demarcation. The bladder demarcations will then be the target for an image-guided boost delivered precisely to the expected tumor site.

Inclusion Criteria:

• Muscle invasive bladder cancer (transitional carcinoma)
• Unifocal
• TNM stage T2a-4a, N0-1, M0
• unfit for radical cystectomy

Exclusion Criteria:

• Hyperthyroidism
• Multinodular goiter
• Pregnancy
• Breast feeding
• WHO preformance status more than 2
• Iodine allergy
• MRI or CT contrast media allergy
• Bi-lateral hip-prosthesis