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| ID | Type | Description | Link |
|---|---|---|---|
| PF334 |
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The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Experimental | Healthy controls |
|
| Postural Tachycardia Syndrome | Experimental | Patients with Postural Tachycardia Syndrome |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Angiotensin II | Drug | Angiotensin II infusion for 1 hour |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean Arterial Blood Pressure Change | Change in MAP from baseline to after 1h of infusion. | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma Renin Activity | Change in plasma renin activity from baseline to after 1h of infusion. | 1 hour |
| Aldosterone Level | Change in aldosterone blood level from baseline to after 1h of infusion. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vanderbilt University | Nashville | Tennessee | 37232 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22247480 | Derived | Mustafa HI, Raj SR, Diedrich A, Black BK, Paranjape SY, Dupont WD, Williams GH, Biaggioni I, Robertson D. Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndrome. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):173-80. doi: 10.1161/CIRCEP.111.965343. Epub 2012 Jan 13. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Control | Healthy controls Angiotensin II: Angiotensin II infusion for 1 hour |
| FG001 | Postural Tachycardia Syndrome | Patients with Postural Tachycardia Syndrome Angiotensin II: Angiotensin II infusion for 1 hour |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Control | Healthy controls Angiotensin II: Angiotensin II infusion for 1 hour |
| BG001 | Postural Tachycardia Syndrome | Patients with Postural Tachycardia Syndrome Angiotensin II: Angiotensin II infusion for 1 hour |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Mean Arterial Blood Pressure Change | Change in MAP from baseline to after 1h of infusion. | Posted | Mean | Standard Error | mmHg | 1 hour |
|
|
1 day
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Control | Healthy controls Angiotensin II: Angiotensin II infusion for 1 hour |
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This was a single center, acute study.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Hossam Mustafa | Vanderbilt University Medical Center | 615-343-6499 | adcresearch@vanderbilt.edu |
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| ID | Term |
|---|---|
| D054972 | Postural Orthostatic Tachycardia Syndrome |
| D054971 | Orthostatic Intolerance |
| ID | Term |
|---|---|
| D054969 | Primary Dysautonomias |
| D001342 | Autonomic Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D000804 | Angiotensin II |
| ID | Term |
|---|---|
| D000809 | Angiotensins |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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| 1 hour |
| Cortisol Level | Change in cortisol blood level from baseline to after 1h of infusion. | 1 hour |
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants |
|
| Participants |
|
|
| Secondary | Plasma Renin Activity | Change in plasma renin activity from baseline to after 1h of infusion. | Posted | Mean | Standard Error | micrograms/deciliter | 1 hour |
|
|
|
| Secondary | Aldosterone Level | Change in aldosterone blood level from baseline to after 1h of infusion. | Posted | Mean | Standard Error | picogram/milliliter | 1 hour |
|
|
|
| Secondary | Cortisol Level | Change in cortisol blood level from baseline to after 1h of infusion. | Posted | Mean | Standard Error | ng/ml/h | 1 hour |
|
|
|
| 0 |
| 13 |
| 0 |
| 13 |
| 0 |
| 13 |
| EG001 | Postural Tachycardia Syndrome | Patients with Postural Tachycardia Syndrome Angiotensin II: Angiotensin II infusion for 1 hour | 0 | 15 | 0 | 15 | 0 | 15 |
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| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |