The Renin-Aldosterone Axis in Postural Tachycardia Syndrome

The Renin-Aldosterone Axis in Postural Tachycardia Syndrome

The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.

Inclusion Criteria:

• Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria
• Age between 18-64 years
• Male or females are eligible
• Able and willing to provide informed consent
• Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study

Exclusion Criteria:

• Overt cause of postural tachycardia e.g., dehydration
• Inability to give or withdraw informed consent
• Pregnancy
• Hypertension (BP > 140/90)
• Significant co-morbid condition
• Other factors which in the investigator's opinion would prevent the subject from completing the protocol