Diagnostic Usefulness of Interferon Gamma Release Assay for Active Tuberculosis in Immunocompromised Patients

For diagnosis of active tuberculosis, interferon-γ release assay based mycobacterium tuberculosis specific antigen may show higher sensitivity than tuberculin skin test in immunocompromised patients. Therefore, interferon-γ release assay have a role as a rapid diagnostic adjunctive methods for active tuberculosis in immunocompromised patients.

Inclusion Criteria:

• Patient suspicious of active tuberculosis with immunocompromised condition

• Immunocompromised condition patients with

  1. solid cancer with chemotherapy
  2. hematologic malignancy
  3. organ transplantation
  4. immunosuppressant
  5. ESRD on renal replacement therapy
  6. diabetes
  7. advanced liver cirrhosis

Exclusion Criteria:

• Patients with

  1. less than 20 years
  2. who don't agree the participation of study
  3. hypersensitivity history to tuberculin
  4. pregnancy