Esmolol in Cardiac Surgery

Esmolol in Cardiac Surgery. A Randomized Controlled Trial With Clinical

This large randomized double-blind clinical trial (esmolol vs placebo) will enroll patients undergoing cardiac surgery to study the additive cardiac protection of this therapeutic strategy.

Inclusion Criteria:

• end diastolic diameter >60 mm and/or an ejection fraction <50%
• written informed consent
• age >18 years

Exclusion Criteria:

• previous unusual response to esmolol
• inclusion in other randomized studies
• esmolol administration in the previous 30 days
• emergency operation