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| ID | Type | Description | Link |
|---|---|---|---|
| R01HD037119 | U.S. NIH Grant/Contract | View source | |
| F32HD063343-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Ajinomoto USA, INC. | INDUSTRY |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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There is a paucity of information on whether and how the composition of formulas fed to infants influences their short-term feeding behaviors during the first few months of life. The purpose of this study is to investigate whether the composition of infant formula affects infants' feeding behaviors, in particular, how much formula is consumed within a given feed (i.e., measure of satiation) and how much time elapses after the feed until the infant exhibits signs of hunger (i.e., measure of satiety). The investigators will also examine the relationship between the composition of infant formula consumed and infant temperature, activity, sleep, and mothers' perceptions of infants' intake and regulatory behaviors.
This is a within-subject, 3-day study. Each mother-infant dyad will visit the Monell Center three times, for 5 hours each time. The protocol during the three visits will be identical. Upon arrival, the infant will be changed into a light-weight cotton body suit. Infants and mothers will be weighed and measured for height. An activity sensor will be placed on the infant and temperature sensors will be placed on both the infant and the mother. When the infant signals hunger, he/she will be fed one of three formulas in randomized order:
Intake will be monitored and all feeds will be videotaped. In between feedings, infants will rest or sleep on their backs in a crib and mothers will fill out questionnaires.
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| Measure | Description | Time Frame |
|---|---|---|
| Satiation: volume of formula consumed within a feed | 5-hour period | |
| Satiety: the duration between feedings | 5-hour period |
| Measure | Description | Time Frame |
|---|---|---|
| Infant temperature change | 5-hour period | |
| Infant sleep and activity patterns | 5-hour period | |
| Maternal perceptions |
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Inclusion Criteria:
Exclusion Criteria:
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Mothers with healthy infants who are between the ages of 1 to 4 months and are exclusively feeding cows milk-based formulas will be recruited from the Philadelphia area for this within-subject experimental research study.
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| Name | Affiliation | Role |
|---|---|---|
| Julie A Mennella, Ph.D. | Monell Chemical Senses Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Monell Chemical Senses Center | Philadelphia | Pennsylvania | 19104 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8960567 | Background | Mennella JA, Beauchamp GK. Developmental changes in the acceptance of protein hydrolysate formula. J Dev Behav Pediatr. 1996 Dec;17(6):386-91. doi: 10.1097/00004703-199612000-00003. | |
| 22357724 | Derived | Ventura AK, Beauchamp GK, Mennella JA. Infant regulation of intake: the effect of free glutamate content in infant formulas. Am J Clin Nutr. 2012 Apr;95(4):875-81. doi: 10.3945/ajcn.111.024919. Epub 2012 Feb 22. |
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DNA collected for analysis of taste receptor and obesity-related genes
| 5-hour period |