Reactogenicity Study of Cervarix and Gardasil in UK Adolescent Girls

A Phase IV, Randomised Study to Evaluate the Immune Responses of UK Adolescent Girls Receiving CervarixTM or GardasilTM Human Papillomavirus Vaccines

This is a phase IV study to evaluate the body's immune response of participants to the Cervarix and Gardasil vaccines against the Human Papilloma Virus (HPV) types associated with increased risk of cervical cancer.

This study looks at possible cross reactivity between different HPV serotypes and both peripheral antibodies and mucosally-secreted antibodies.

Inclusion Criteria:

• Aged between 13 and 15 years at the time of the first immunisation
• Female
• No contraindications to vaccination as specified in the "Green Book" - Immunisation Against Infectious Disease, HMSO.
• Written informed consent obtained from parent or guardian of subject

Exclusion Criteria:

• Pregnant or become pregnant during the course of the trial (no contraindications to vaccination for those taking the contraceptive pill).
• Breast-feeding mothers
• Allergic to vaccine components