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This study will evaluate the safety and tolerability of repeated subcutaneous injections of CAD106 in patients with Alzheimer's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAD106 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CAD106 | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety/tolerability assessments at multiple timepoints including but not limited to screening, and through to the end of the study to week 66. | 66 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Immune response, cognitive and functional assessments at multiple timepoints including but not limited to baseline and through to the end of the study to week 66. | 66 weeks | |
| Evaluate the antibody response after 4 additional injections in the Extension study in patients initially treated with CAD106 in the Core study. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Novartis Pharmaceuticals | Novartis Pharmaceuticals | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Novartis Investigative Site | Bordeaux | France | ||||
| Novartis Investigative Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25918556 | Derived | Farlow MR, Andreasen N, Riviere ME, Vostiar I, Vitaliti A, Sovago J, Caputo A, Winblad B, Graf A. Long-term treatment with active Abeta immunotherapy with CAD106 in mild Alzheimer's disease. Alzheimers Res Ther. 2015 Apr 27;7(1):23. doi: 10.1186/s13195-015-0108-3. eCollection 2015. |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D002493 | Central Nervous System Diseases |
| D019636 | Neurodegenerative Diseases |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
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| 66 weeks |
| Collect long-term safety information through SAEs collection for two years after completion of the core study, CAD106A2201, or extension study, CAD106A2201E1. | 2 years |
| Stockholm |
| Sweden |
| Novartis Investigative Site | Basel | Switzerland |
| Novartis Investigative Site | Southampton | United Kingdom |
| D019965 |
| Neurocognitive Disorders |
| D001523 | Mental Disorders |