ONO-7746 Study in Healthy Adult Subjects

A Double-Blind, Placebo-Controlled, SIngle Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONO-7746 in Healthy Adult Subjects

The primary objective of this study is to evaluate the safety and tolerability of ONO-7746 in healthy adult subjects. The secondary objectives are to characterize the pharmacokinetic and pharmacodynamic profiles of ONO-7746.

Inclusion Criteria:

• Healthy non-smoking male or female subjects (18-55 years inclusive)
• Body mass index (BMI) of 19-35 kg/m² (inclusive)
• For females: postmenopausal, non-lactating and non-pregnant

Exclusion Criteria:

• History or presence of clinically significant disease