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The purpose of this study is to compare oxidative stress markers and the immunologic characteristics of HIV-infected and non-HIV subjects during a bout of moderate aerobic exercise followed by resistance exercises
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIV Group | HIV infected persons | ||
| Control Group | Non HIV-infected persons |
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| Measure | Description | Time Frame |
|---|---|---|
| Total Glutathione | The total glutathione content in erythrocyte concentrate at three moments: baseline, aerobic and resistance exercise. | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
| Measure | Description | Time Frame |
|---|---|---|
| Catalase Activity | Antioxidant activity of the catalase enzyme at three moments: baseline, aerobic and exercise. | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
| Glutathione S-transferase (GST) |
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Inclusion Criteria:
Exclusion Criteria:
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The participants of the HIV group were recruited at the outpatient HIV/AIDS care unit of the Hospital de ClÃnicas de Porto Alegre (HCPA), whereas the control group (non-HIV) was formed by volunteers of the city of Porto Alegre, Rio Grande do Sul, Brazil
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| Name | Affiliation | Role |
|---|---|---|
| Pedro Dall'Ago, Professor | Hospital de Clinicas de Porto Alegre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Outpatient HIV/AIDS care unit of the Hospital de ClÃnicas de Porto Alegre | Porto Alegre | Rio Grande do Sul | 90035-903 | Brazil |
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| ID | Title | Description |
|---|---|---|
| FG000 | HIV Group | HIV infected persons |
| FG001 | Control Group | Non HIV-infected persons |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | HIV Group | HIV infected persons |
| BG001 | Control Group | Non HIV-infected persons |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Secondary | Catalase Activity | Antioxidant activity of the catalase enzyme at three moments: baseline, aerobic and exercise. | Posted | Jul 2008 | Median | Inter-Quartile Range | units of catalase /mg protein | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
|
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Pedro Dall'Ago | Hospital de ClÃnicas de Porto Alegre | 555133038751 | pdallago@pq.cnpq.br |
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| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
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Antioxidant activity of the Glutathione S-transferase enzyme at three moments: baseline, aerobic and resistance exercise. |
| 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
| Lipid Peroxidation | Thiobarbituric acid-reactive substances (TBARS) assay was used as an index of lipid peroxidation in erythrocytes, at three moments: baseline, aerobic and resistance exercise. | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
| T CD4 | T CD4 lymphocytes counts at three moments: baseline, aerobic and resistance exercise. | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
| Neutrophil Count | Neutrophil count at three moments: baseline, aerobic and resistance exercise. | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
| Peak Oxygen Uptake | Is the maximum capacity of an individual's body to transport and utilize oxygen during incremental exercise. | 1 time, before the exercise protocol |
| BG002 |
| Total |
Total of all reporting groups |
| Participants |
|
| Age Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Units |
|---|
| Counts |
|---|
| Participants |
|
|
|
| Primary | Total Glutathione | The total glutathione content in erythrocyte concentrate at three moments: baseline, aerobic and resistance exercise. | Posted | Median | Inter-Quartile Range | nmoles glutathione/ ml of sample | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
|
|
|
|
| Secondary | Glutathione S-transferase (GST) | Antioxidant activity of the Glutathione S-transferase enzyme at three moments: baseline, aerobic and resistance exercise. | Posted | Jul 2008 | Median | Inter-Quartile Range | micromol of GST/min/mg of protein | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
|
|
|
|
| Secondary | Lipid Peroxidation | Thiobarbituric acid-reactive substances (TBARS) assay was used as an index of lipid peroxidation in erythrocytes, at three moments: baseline, aerobic and resistance exercise. | Posted | Jul 2008 | Median | Inter-Quartile Range | picomol of TBARS/mg protein | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
|
|
|
|
| Secondary | T CD4 | T CD4 lymphocytes counts at three moments: baseline, aerobic and resistance exercise. | Posted | Jul 2008 | Median | Inter-Quartile Range | Cell/ul of blood | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
|
|
|
|
| Secondary | Neutrophil Count | Neutrophil count at three moments: baseline, aerobic and resistance exercise. | Posted | Jul 2008 | Median | Inter-Quartile Range | Cell/ul of blood | 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise). |
|
|
|
|
| Secondary | Peak Oxygen Uptake | Is the maximum capacity of an individual's body to transport and utilize oxygen during incremental exercise. | Posted | Jul 2008 | Median | Standard Deviation | ml/min | 1 time, before the exercise protocol |
|
|
|
|
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| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| Resistance |
|
Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences
| <0.05 |
| 95 |
| No |
| Superiority or Other |
| Friedman Test | Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences | <0.05 | 95 | No | Superiority or Other |
| Resistance |
|
Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences
| <0.05 |
| 95 |
| No |
| Superiority or Other |
| Friedman Test | Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences | <0.05 | 95 | No | Superiority or Other |
| Resistance |
|
Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences
| <0.05 |
| 95 |
| No |
| Superiority or Other |
| Friedman Test | Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences | <0.05 | 95 | No | Superiority or Other |
| Resistance |
|
Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences
| <0.05 |
| 95 |
| No |
| Superiority or Other |
| Friedman Test | Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences | <0.05 | 95 | No | Superiority or Other |
| Resistance |
|
Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences
| <0.05 |
| 95 |
| No |
| Superiority or Other |
| Friedman Test | Friedman to compare: baseline vs. aerobic, baseline vs. resistance and aerobic vs. resistance. Wilcoxon was applied to locate the differences | <0.05 | 95 | No | Superiority or Other |