Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI)

A Multicenter,Investigator-blinded,Randomized, Comparative Study to Evaluate the Efficacy and Safety of Oral NXL103 Versus Oral Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)

The objective of this study is to evaluate the efficacy and safety of oral NXL103 vs. established treatment of acute bacterial infection in adults.

Inclusion Criteria:

• Diagnosed with acute bacterial skin and skin structure infection (ABSSSI) with at least 3 signs or symptoms

Exclusion Criteria:

• Uncomplicated acute bacterial skin and skin structure infections
• ABSSSI suspected or proven to be due to Gram negative and/or anaerobic pathogens
• Pregnant or lactating women
• Inadequately controlled diabetes mellitus
• Inadequately controlled arterial hypertension
• Moderate-to-severe renal impairment
• Moderate-to-severe liver disease
• Conditions associated with immunodeficiency
• Known hypersensitivity or any contraindication for the use of any of the 2 study drugs