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Perioperative airway resistance and lung function are evaluated perioperatively in patients, who undergo surgical procedures in different postures and with or without gas insufflation into the peritoneal cavity.
Lung function, upper and lower airway resistance measurements are performed in patients in prone horizontal or head tilted down (40°) position. Half of the patients with head down position will have surgery in laparoscopic technique (including gas insufflation to achieve a pneumoperitoneum). Measurements are performed on the day prior to surgery, on the morning of surgery, 30 - 45 minutes, 2 hours, and 24 hours after extubation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| head down, laparoscopic | 20 patients with laparoscopic surgery (radical robotic prostatectomy) in head down position | ||
| head down, open | 20 patients undergoing "open"surgery (open radical prostatectomy) in head down position. | ||
| horizontal, open | 20 patients undergoing "open" surgery in horizontal position (open hemicolectomy) |
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| Measure | Description | Time Frame |
|---|---|---|
| Measurement of FEV1 (forced expiratory volume in one second) and the MEF50/MIF50 ratio | 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in nasal airway resistance | 18 months |
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Inclusion Criteria:
Exclusion Criteria:
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20 patients scheduled for "robotic" prostatectomies 20 patients scheduled for open prostatectomies 20 patients scheduled for open hemicolectomies
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Harald Groeben, Prof. Dr. | Contact | ##49201174 | 31109 | h.groeben@kliniken-essen-mitte.de |
| Name | Affiliation | Role |
|---|---|---|
| Harald Groeben, Prof. Dr. | Klniken Essen-Mitte | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prof. Dr. Harald Groeben | Recruiting | Essen | 45136 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7006464 | Background | Craig DB. Postoperative recovery of pulmonary function. Anesth Analg. 1981 Jan;60(1):46-52. No abstract available. | |
| 19417617 | Background | Herbstreit F, Peters J, Eikermann M. Impaired upper airway integrity by residual neuromuscular blockade: increased airway collapsibility and blunted genioglossus muscle activity in response to negative pharyngeal pressure. Anesthesiology. 2009 Jun;110(6):1253-60. doi: 10.1097/ALN.0b013e31819faa71. |
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| ID | Term |
|---|---|
| D011027 | Pneumoperitoneum |
| ID | Term |
|---|---|
| D010532 | Peritoneal Diseases |
| D004066 | Digestive System Diseases |
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| 16998093 | Background | Chiu KL, Ryan CM, Shiota S, Ruttanaumpawan P, Arzt M, Haight JS, Chan CT, Floras JS, Bradley TD. Fluid shift by lower body positive pressure increases pharyngeal resistance in healthy subjects. Am J Respir Crit Care Med. 2006 Dec 15;174(12):1378-83. doi: 10.1164/rccm.200607-927OC. Epub 2006 Sep 22. |