Effects of Sulforaphane on Normal Prostate Tissue

In Vivo Effects of Sulforaphane Supplementation on Normal Human Prostate

The investigators proposed to identify the biological effects of a high-sulforaphane broccoli sprout extract in normal prostate tissue.

The investigators hypothesize that consumption of high-sulforaphane broccoli sprout extract every other day will inhibit growth of prostate cancer cells.

Inclusion Criteria:

• Men aged 40-75 years
• Low or intermediate grade prostate cancer (as defined by Gleason sum less than or equal to 7) and clinical stage T1 or T2
• Serum Prostate specific antigen less than 20 ng/ml
• Have elected radical prostatectomy, Brachytherapy or active surveillance as their primary treatment

Exclusion Criteria:

• No current physician diagnosed disease (including but not limited to): kidney disease requiring dialysis, cognitive deficits, substance abuse
• BMI < 18.5 kg/m2 or > 40 kg/m2
• Use of any hormonal treatments, including but not limited to testosterone
• Any previous cancer diagnosis or treatment within the previous five years, excluding non-melanoma skin cancer
• Inability or unwillingness to eat a diet that is free of Brassica vegetables for the duration of the study
• Use of any dietary supplements other than a multivitamin (including herbal preparations)
• Allergy to cruciferous vegetables or any of the specific fillers used in the placebo
• Usual consumption of > 5 servings per week of Brassica vegetables