A Study to Assess the Bioequivalence of Aprepitant and Fosaprepitant and the Effect of Food on Aprepitant Bioavailability (0869-165)

A Single-Dose Bioequivalence and Food Effect Study With Aprepitant and Fosaprepitant Dimeglumine in Healthy Young Adult Subjects

This study will assess the bioequivalence of single oral doses of aprepitant (MK0869) to a single intravenous infusion of fosaprepitant (MK0517) and also determine the effect of food on the bioavailability of oral aprepitant.

Inclusion Criteria:

• Subject is in good health
• Subject is a nonsmoker
• Subject is willing to comply with the study restrictions

Exclusion Criteria:

• Subject has a history of any illness that might confound the results of the study or might make participation in the study unsafe
• Subject has a history of stroke, seizures, or major neurological disorder
• Subject has a history of cancer
• Subject consumes more than two alcoholic drinks per day
• Subject consumes more than three caffeinated beverages daily