A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer | NCT00943891 | Trialant
Unknown statusObservationalUpdated Jan 22, 2014
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
ClinicalTrials.gov ID
NCT00943891
Lead Sponsor
National University Hospital, SingaporeOTHER
Overall Status
Unknown status
Study Type
Observational
Enrollment
500
Last Update Posted
Jan 22, 2014Estimated
Start Date
Jul 2008
Primary Completion Date
Dec 2014Estimated
Completion Date
Dec 2014Estimated
Official Title
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
Brief Summary
To determine the association between LVD and clinico-pathologic variables in archived colorectal cancer and Nasopharyngeal carcinoma specimens
To determine the association between VEGF-C,-D expression with COX-2 expression and clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma
To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer. Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma, the investigators intend to analyze archived specimens collected in a previously conducted study. Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD, LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques. Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised methods.