MK0524B Bioequivalence Study (0524B-070)

An Open-Label, Definitive Bioequivalence Study to Compare the Pharmacokinetics of the Simvastatin, Nicotinic Acid, and MK0524 (Laropiprant) Components of a Formulation of MK0524B With That of Zocor™ and MK0524A Tablets

This study will evaluate:

1. the bioequivalence of simvastatin and simvastatin acid following dose of simvastatin (ZOCOR™) given together with one tablet of MK0524A or as a component of the triple combination tablet MK0524B.
2. the bioequivalence of laropiprant and ER niacin when administered as the triple combination tablet MK0524B or as the double combination tablet MK0524A given together with simvastatin.

Inclusion Criteria:

• Subject is in good health
• Subject is a nonsmoker
• Subject is willing to follow the study guidelines

Exclusion Criteria:

• Subject has or has a history of any illness that might confound the results of the study or make participation in the study unsafe for the subject