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The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.
The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No treatment | Consecutive patients undergoing emergency surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Occurence of Adverse Cardiac Events | Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death). Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality. Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure. | postoperatively (index surgery) until a median follow-up of 34 months |
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| Measure | Description | Time Frame |
|---|---|---|
| NT-ProBNP Preoperative | NT-ProBNP was measured 0-24 hours before induction of anesthesia | 0-24 hours before induction of anesthesia |
| Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events |
Inclusion criteria:
Emergency surgery:
Vascular
Intra-abdominal
Orthopedic
Exclusion Criteria:
Patients unable to provide informed consent
Thoracic surgery
Trauma surgery
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Consecutive patients undergoing emergency non-cardiac surgery
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| Name | Affiliation | Role |
|---|---|---|
| Elisabeth Mahla, M.D. | Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesia and Intensive Care Medicine | Graz | 8036 | Austria |
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| ID | Title | Description |
|---|---|---|
| FG000 | No Treatment | Consecutive patients undergoing emergency surgery |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | One Arm | consecutive patients presenting for emergent non-cardiac surgery |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Occurence of Adverse Cardiac Events | Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death). Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality. Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure. | Posted | Number | participants | postoperatively (index surgery) until a median follow-up of 34 months |
|
Median follow-up of 34 months
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | One Arm | consecutive patients presenting for emergent non-cardiac surgery Patients were followed for occurence of major adverse cardiac events |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Serious Adverse cardiac events | Cardiac disorders | Systematic Assessment |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Elisabeth Mahla, MD | Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Austria | ++43316385 | 13027 | elisabeth.mahla@medunigraz.at |
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one vial of serum per patient is retained
Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events
| postoperatively (index surgery) until a median follow-up of 34 months |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Units | Counts |
|---|---|
| Participants |
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| Other Pre-specified | NT-ProBNP Preoperative | NT-ProBNP was measured 0-24 hours before induction of anesthesia | Consecutive patients undergoing emergent non-cardiac surgery | Posted | Median | Inter-Quartile Range | pg/ml | 0-24 hours before induction of anesthesia |
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| Other Pre-specified | Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events | Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events | Posted | Median | Inter-Quartile Range | pg/ml | postoperatively (index surgery) until a median follow-up of 34 months |
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| 91 |
| 297 |
| 0 |
| 297 |
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