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To assess the efficacy of inhaled AIR645 in the suppression of the Asthmatic Responses in subjects with mild asthma inhaling an allergen.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AIR645 | Experimental | AIR645 (an IL-4/IL-13 dual cytokine signaling inhibitor) solution (diluent: physiologic saline solution) |
|
| Physiologic saline solution | Placebo Comparator | Physiologic saline solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AIR645 | Drug | AIR645 (blinded) by nebulization, range of doses, maximum of one dose per day, maximum of 6 doses in 22 days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the curve (AUC) of the percentage decrease forced expiratory volume in one second (FEV1) from baseline between AIR645 and placebo | 36 days |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mike Hodges, MD | Altair Therapeutics, Inc. | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hamilton | Ontario | Canada | ||||
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D006967 | Hypersensitivity |
| D008173 | Lung Diseases, Obstructive |
| D007154 | Immune System Diseases |
| D012140 | Respiratory Tract Diseases |
| D001982 | Bronchial Diseases |
| D008171 | Lung Diseases |
| D006969 | Hypersensitivity, Immediate |
| D012130 | Respiratory Hypersensitivity |
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| Physiologic saline solution | Drug | Placebo (blinded) by nebulization, range of doses, maximum of one dose per day, maximum of 6 doses in 22 days. |
|
| Laval |
| Quebec |
| Canada |
| Saskatoon | Saskatchewan | Canada |