Study of the Effect of Single Doses of MK2637 and Dextromethorphan on Cerebral Cortex Excitability (2637-008)

A Randomized Clinical Trial to Assess the Effects of Single Doses of MK2637 and Dextromethorphan on Cerebral Cortex Excitability in Healthy Subjects

This study will assess transcranial magnetic stimulation (TMS) as a biomarker and characterize TMS readouts of the activity of MK2637 and dextromethorphan. Resting quantitative electroencephalography(qEEG) readouts are also characterized with MK2637 and dextromethorphan.

Inclusion Criteria:

• Subject is right-handed
• Subject is in good health
• Subject is a nonsmoker

Exclusion Criteria:

• Subject works a night shift
• Subject has a history of any illness that might make participation in the study unsafe or confound the study results
• Subject has a history of head injury