The study aim is to evaluate the long term outcome of intra-coronary autologous bone marrow (BM) transplantation in patients with severe ischemic cardiomyopathy without the option for revascularization.

Several studies have demonstrated the short term safety, feasibility and efficacy of cell transplantation in patients with advanced heart failure. There are no data about the long term outcome.

Inclusion Criteria:

• Patients with evidence of hibernation and/or ischemia in at least 2 different myocardial segments underwent coronary angiography

Exclusion Criteria:

• Idiopathic or non-ischemic cardiomyopathy
• Other etiology for heart failure, history of past or current disease involving the bone marrow
• Patients on dialysis
• Positive serologic test for HIV, hepatitis B or C or any neoplastic or terminal disease