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The purpose of this study is to examine whether the speed of the clinical antidepressant action of citalopram can be accelerated by administering double doses of pindolol (15 mg/day, tid) which presumably should lead to increased 5-HT1A autoreceptor occupancy.
Design, Settings, and Participants. A randomised, double-blind, placebo-controlled trial with MDD patients allocated to two treatment arms: citalopram + pindolol versus citalopram + placebo. Participants: outpatients with a depressive episode (DSM-IV criteria) were selected from a general hospital.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Citalopram + placebo | Placebo Comparator | Citalopram 20 mg/day t.i.d |
|
| Citalopram + pindolol | Experimental | Citalopram 20 mg/day t.i.d Pindolol 15 mg/day t.i.d. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pindolol | Drug | Pill orally administered. 15 mg/day t.i.d. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Scores on Hamilton Depression Rating Scale | 8 time points through 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Enric Álvarez, MD, PhD | Department of Psychiatry. Hospital de la Santa Creu i Sant Pau | Principal Investigator |
| Víctor Pérez, MD, PhD | Department of Psychiatry. Hospital de la Santa Creu i Sant Pau | Study Director |
| Francesc Artigas, PhD | Neurochemistry department. Consejo Superior de Investigaciones Científicas | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Outpatients Service of Psychiatry Department. Hospital de la Santa Creu i Sant Pau | Barcelona | Catalonia | 08025 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21034693 | Derived | Portella MJ, de Diego-Adelino J, Ballesteros J, Puigdemont D, Oller S, Santos B, Alvarez E, Artigas F, Perez V. Can we really accelerate and enhance the selective serotonin reuptake inhibitor antidepressant effect? A randomized clinical trial and a meta-analysis of pindolol in nonresistant depression. J Clin Psychiatry. 2011 Jul;72(7):962-9. doi: 10.4088/JCP.09m05827blu. Epub 2010 Oct 19. |
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| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| C537907 | Barakat syndrome |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D010869 | Pindolol |
| ID | Term |
|---|---|
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
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| D009930 |
| Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |