The Prognostic Significance of Fibrosis Detection in Cardiomyopathy

The Prognostic Significance of Fibrosis Detection in Ischemic and Non-ischemic Cardiomyopathy

The presence of scar within heart muscle can act as a substrate for abnormal rhythm problems and lead to the developement of heart failure

Clinical significance Correlation with biomarkers and genetic markers

Patients will undergo cardiovascular magnetic resonance (CMR) to include measurement of left ventricular volumes, ejection fraction, detection of inflammation (via STIR sequences) where appropriate, early gadolinium enhancement, late gadolinium enhancement, first pass perfusion using pharmacological stress imaging (contraindications to include comorbidities that do not permit pharmacological stress agents e.g. severe asthma, severe or symptomatic aortic stenosis)

Inclusion Criteria:

• presence of an ischaemic or non-ischaemic cardiomyopathic process
• no contraindication to contrast enhanced CMR
• GFR >30

Exclusion Criteria:

• ESRF
• Contraindication to CM R