The endomicroscopy is an adaptation of traditional optical microscopy in the digestive endoscopy. Furthermore, with the integration of a miniaturized laser confocal microscope to a videoendoscope, it's possible to study the digestive mucous by "optical biopsy". This monocentric, non randomized and prospective study uses the Intra-ductal confocal endomicroscopy for the characterization of pancreas and bile duct tumor.

Primary objective:

Obtain a tissular characterization of a biliary or pancreatic stenosis with a confocal microscope which is in direct contact of the stenosis during the Endoscopic Retrograde Cholangio-Pancreatography (ERCP).

Secondary objectives:

• Compare the result of this "optical biopsy" to a conventional biopsy.
• Tolerance

Inclusion Criteria:

• Patients aged from 18 to older
• Patient with an inflammatory or tumoral stenosis of bile duct or a solid or cystic tumor in the pancreas with a dilatation of the principal pancreatic canal.
• Signed consent

Non inclusion Criteria:

• Patient who have no indication for an ERCP
• Allergy to fluorescein
• Allergic rhinitis, asthma, eczema
• Pregnancy, breast feeding
• Patients with dialysis
• Patient with severe heart failure
• Patient with cirrhosis
• Hemostasis failure which can induce difficulties or contraindication for the biopsy during the conventional endoscopy