Azelaic Acid Versus Hydroquinone in Melasma

Efficacy & Safety of Azelaic Acid 15% Gel vs. Hydroquinone 4% Cream in the Treatment of Melasma

The purpose of this study is to compare the safety and effectiveness of Azelaic Acid Gel to Hydroquinone Cream in the treatment of melasma.

Melasma is a chronic condition in which dark areas appear on the forehead, cheeks, and upper lips. Hydroquinone is a skin lightener (or fade cream) and is one of the most commonly used medications for the treatment of melasma. Azelaic acid gel is currently used to treat acne and rosacea.

Inclusion Criteria:

• must have stable moderate-severe epidermal or mixed melasma involving the face
• all races
• males and females
• persons taking birth control medication, hormone replacement therapy or any other hormone altering medication may participate only if they have not started or stopped the medication within the last 3 months

Exclusion Criteria:

• if the person has only dermal melasma
• pregnancy, breastfeeding, a positive pregnancy test in the office or plans to become pregnant
• a known allergy or sensitivity ot azelaic acid or hydroquinone
• the use of photosensitizing medications (ex. tetracycline) within 3 months of the study.
• starting or stopping hormonal medication within 3 months
• chemical peels, microdermabrasion, or laser treatment within 6 months
• worsening or improving melasma